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Heparina(Heparin  ) was discovered by Mac Lean in 1916. It has been medically important as an anticoagulant since its introduction over a half-century ago, and recently a number of new biological activities has been adscribed to it.
Heparina(Heparin ) is a very complex glycosaminoglycan composed of alternate sequences of uronic acid (usually -L-iduronic acid) and -D-glucosamine linked by (14)bonds, with sulphate groups in the glucosamine ring.
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Heparina(Heparin ) is polydisperse in chain length and heterogeneous in degree and type of sulfatation.
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CAS NO. 9041-08-1
EINECS NO. 2326817 |
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Heparin(Heparin ) possesses numerous activities, but the most important is its anticoagulant property.
Heparin(Heparin ) forms a complex with Antithrombin III, and inhibits several activated blood coagulation factors: XIIa, XIa, Xa, IIa, Thrombin and Kallikrein.
It is also used as a thrombolytic, fat-clearing antiartherosclerotic and as a pottentially effective antiinflammatory agent.
- Acute phase myocardial infartus.
- Prophylactic and curative treatment of venous and arterial thromboembolism.
- Pulmonary embolism.
- Prevention of pulmonary thromboembolism and deep venous thrombosis in pregnancy.
- Peripheral obliterative arterial diseases.
- Atherosclerosis.
- Extra-corporeal circulation (ECC).
- Hemodyalisis.
- Extra-corporeal therapies, such as heart-lung oxygenation and kidney dialysis.
- Open heart surgeries.
- Deep phlebitis.
- Vitreoretinal surgery.
- Topical application on flap survival.
- Topical application for leg ulcers.
A wide range of novel biological activities have recently been under research. Due to their structural complexity and high capacity of biological interaction, Heparin(Heparin ) and its derivates are molecules with a huge potential for the development of novel drugs.
The activity of Heparin(Heparin ) is currently being studied in the treatment of numerous diseases:
· Cancer
· Chronic obstructive pulmonary disease (COPD)
· Organ transplants
· Allergic encephalomyelitis
· Allergic rhinitis
· Arthritis
· Asthma
· Irritable bowel syndrome
· Pulmonary emphysema
· Interstitial cystitis
Many of these studies are in an advanced stage of clinical development, and some of them are supported by Bioiberica Heparin Science.
Packed in three plastic bags inside a metal drum weighing 2, 10, 25 and 80 Kg, depending on order quantity.
Heparin(Heparin ) is currently available in bulk quantities. It is presented in solid powder form. The qualities available are:
- Sodium heparin
- Lithium heparin
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Menu Heparin
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